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Microbiology (~10%) and immunology (~6%) — combined ~16% of Step 1, plus heavy integration with infectious-disease pathology and antimicrobial / immunosuppressant pharmacology. AIIMS-trained biology faculty layer mechanism pedagogy on top of Sketchy visual mnemonics — the missing application layer that Sketchy alone doesn't provide. 3-week microbiology block + 3-week immunology block within the full Step 1 programme; $175/hour ad-hoc for targeted gap-fill.
WhatsApp +91 88264-44334Microbiology is approximately 10% and immunology approximately 6% of Step 1 — combined, this is ~16% of total content. Both are heavily integrated with pathology (infectious disease pathology) and pharmacology (antibiotics, antifungals, antivirals, immunosuppressants), which amplifies their real impact above the headline weighting.
Yes. Sketchy Microbiology and Sketchy Immunology are the dominant visual-mnemonic resources in the US Step 1 prep market, and we expect most students to be using them. Cerebrum supplements Sketchy with the biology-mechanism pedagogy that visual mnemonics alone do not provide — for example, Sketchy will help you remember the surface antigens of Strep pneumoniae, but a Cerebrum session will explain why the polysaccharide capsule is the dominant virulence factor and how that drives both the clinical presentation and the vaccine target choice. We do not replicate Sketchy content — we layer on top of it.
Top 10 highest-yield Step 1 microbiology topics: (1) gram-positive cocci (Strep, Staph) with toxin profiles, (2) gram-negative diarrhea bugs (Salmonella, Shigella, E. coli including EHEC/O157:H7), (3) atypical pneumonia bugs (Mycoplasma, Legionella, Chlamydia, Coxiella), (4) the Herpes family and reactivation patterns, (5) HIV pathophysiology + ART mechanisms, (6) parasitic infections with classic clinical pearls (malaria, Chagas, schistosomiasis), (7) fungal infections in immunocompromised hosts (Aspergillus, Cryptococcus, Pneumocystis), (8) major antibiotic classes + resistance mechanisms, (9) bacterial vaccines (toxoid, conjugate, polysaccharide), (10) congenital infections (TORCHeS).
Top 8 highest-yield Step 1 immunology topics: (1) hypersensitivity types I–IV with classical clinical examples, (2) complement system + activation pathways + deficiencies (C1 inhibitor, C5–C9 / Neisseria susceptibility), (3) MHC class I vs class II antigen presentation, (4) T-cell receptor signalling + co-stimulation, (5) B-cell maturation + immunoglobulin class switching, (6) primary immunodeficiencies (SCID, Bruton XLA, CVID, Chronic Granulomatous Disease, Wiskott-Aldrich, DiGeorge), (7) vaccine immunology (live attenuated vs killed vs subunit vs mRNA), (8) transplant immunology (HLA matching, GVHD, hyperacute vs acute vs chronic rejection).